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KMID : 0617819950050010235
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Journal of Wonkwang Oriental Medicine
1995 Volume.5 No. 1 p.235 ~ p.263
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Effects of Ogapi(Acanthopanax senticosus) Water Extract on the Functions of Murine Immunocytes for Antitumor Immunity
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成載煥/Seong, Jae-Hwan
權文鉉/金炯均/Kyweon, Mun-Hyeun/Kim, Hyeong-Kyun
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Abstract
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Ogapi(Acanthopanax senticosus) is being used for a tonic in the oriental medicine from ancient times, Even though it being used frequently for a tonic in the clinical medicine, basic study to make sure the mechanism of its action is the rare.
Therefore, in this study, the author tried to know the effects of ogapi on the innate and specific immune systems in association with antitumor activity. The results obtained in this study are as follows:
1) Ogapi increased the phagocytic activities of murine peritoneal macrophages in vivo and in vitro.
2) Ogapi enhanced the production of such reactive oxygen intermediates as superoxide and hydrogen peroxide from the macrophages in vivo and in vitro.
3) Ogapi enhanced such humoral immune responses as hemagglutinin and hemolysin formations.
4) Administration of ogapi increased the number of rosette forming cells in the spleen.
5) Ogapi decreased the contact hypersensitivity against dinitrofluorobenzene.
6) Ogapi showed cytotoxic activity against human leukemia cell line (K562)
7) Ogapi increased the ratio of helper T cell versus suppressor T cell by increasing CD4^+ T cells and decreasing CD8^+ T cells.
The above results show that ogapi increase the host antimicrobic and antitumor activities by the action on individual innate and specific immune systems in vitro. So this is considered as experimental results back up powerfully that ogapi can be used for a tonic in such a case when administered to a person lacking vital energy.
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